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Stay in Santa Cruz Region's best hotels!

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Wonderful: 9+ Very Good: 8+ Good: 7+ Pleasant: 6+
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Chairu Eco Hotel

Hotel in Santa Cruz de la Sierra

Chairu Eco Hotel features a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra. This 4-star hotel offers a concierge service and a tour desk. Located where I expected to be, as I need to fix some issues in the town, and the office was closer to the hotel. Did not have time to enjoy as my stay was quite short. and left before breakfast. Area is quite safe and I have walked during the night, returing from a chinese restaurant and it was OK.

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9
Wonderful
835 reviews
Price from
$50.16
per night

TRYP by Wyndham Santa Cruz

Hotel in Santa Cruz de la Sierra

Located in Santa Cruz de la Sierra, a 19-minute walk from Gabriel Rene Moreno Autonomous University, TRYP by Wyndham Santa Cruz has accommodations with an outdoor swimming pool, free private parking,... Amazing and modern hotel, with a nice breakfast, friendly and helpful staff and a great location too

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9
Wonderful
410 reviews
Price from
$67.15
per night

YVY CASA HOTEL

Hotel in Samaipata

Located in Samaipata, 6.1 miles from Samaipata Fort, YVY CASA HOTEL provides accommodations with a garden, free private parking and a terrace. This is simply a fantastic place to stay. The architecture is beautiful, and the rooms spacious, with comfortable beds. It is very quiet and relaxing. Breakfast was excellent and staff very friendly and helpful. The hotel is just a short walk away from the center of Samaipata. There’s a kitchen that you can use to cook.

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9.2
Wonderful
249 reviews
Price from
$42.75
per night

Marriott Santa Cruz de la Sierra Hotel

Hotel in Santa Cruz de la Sierra

Marriott Santa Cruz de la Sierra Hotel has an outdoor swimming pool, fitness center, a shared lounge and terrace in Santa Cruz de la Sierra. How we were welcomed by the receptionist Marcela. How Fabricio the bar tender was attentive and eager to please. How Rodrigo was great in the morning during breakfast. Just perfect. Thank you so much for this amazing experience. And again thank you to these three people mentioned above. They deserved to be rewarded.

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9.1
Wonderful
301 reviews
Price from
$118.40
per night

Cosmopolitano Hotel Boutique

Hotel in Santa Cruz de la Sierra

Offering an outdoor pool, Cosmopolitano Hotel Boutique is located in the historical center of Santa Cruz de la Sierra. Guests can enjoy the on-site bar. Service was impeccable. We had to leave at 4:00 am in the morning to catch our flight and they made a full breakfast for us before we left.

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9.1
Wonderful
865 reviews
Price from
$84.36
per night

La Vida es Bella

Hotel in Samaipata

Located in Samaipata, 5.6 miles from Samaipata Fort, La Vida es Bella provides accommodations with a garden, free private parking, a shared lounge and a terrace. Great location. Wonderful service. The best breakfast ever. A perfect place to rest and enjoy Samaipata.

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9.3
Wonderful
119 reviews
Price from
$60
per night

El Pueblito Hotel Boutique

Hotel in Samaipata

Located in Samaipata, 7 miles from Samaipata Fort, El Pueblito Hotel Boutique has accommodations with an outdoor swimming pool, free private parking, a garden and a shared lounge. We loved the charm, comfort and friendly, helpful staff.

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9.5
Exceptional
223 reviews
Price from
$87
per night

Alfonsina Hotel Boutique

Hotel in Santa Cruz de la Sierra

Conveniently located only a 10-minute walk from Ventura Shopping Center, Alfonsina Hotel Boutique. offers accommodations in Santa Cruz de la Sierra. There couldn’t be a better location. Good restaurants, all around.

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9.4
Wonderful
377 reviews
Price from
$94.50
per night

Rústico & Hotel Boutique Las Churapas

Hotel in San José de Chiquitos

Rústico & Hotel Boutique Las Churapas features an outdoor swimming pool, garden, a terrace and bar in San José de Chiquitos. The hotel provides both free WiFi and free private parking. Las Churapas is an amazing place. Owners are kind, helpful, professional, and just very relaxing to be around. The property is gorgeous. I would rather spend a week here than at any of the hotels/resorts in Santa Cruz. Basically, Aidee and Johan make their hotel feel like a peaceful retreat. I will definitely be returning!

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9.2
Wonderful
83 reviews
Price from
$38
per night

Hotel La Casona

Hotel in Camiri

Featuring an outdoor pool this countryside Hotel offers accommodations in Camiri close to the city center. Free private parking is available on site and complimentary buffet breakfast is served daily.... The entire house is beautiful and unexpected considering the rest of town . Quite a surprise after a long journey . The owner is really nice and helpful .

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9.2
Wonderful
13 reviews
Price from
$25
per night

Hotels with extra health and safety measures

Find hotels in Santa Cruz Region with added hygiene measures plus high cleanliness ratings

Safety features
Physical distancing
Cleanliness & disinfection
Food & drink safety

Most-booked hotels in Santa Cruz Region in the past month

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Santa Cruz Region's best hotels with breakfast

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Hotels in Santa Cruz Region you can book without a credit card

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FAQs about hotels in Santa Cruz Region